Professional Search in Pharmaceutical Research

In the mid 90s, visiting libraries – as means of retrieving the latest literature – was still a common necessity among professionals. Nowadays, professionals simply access information by ‘googling’. Indeed, the name of the Web search engine market leader “Google” became a synonym for searching and retrieving information. Despite the increased popularity of search as a method for retrieving relevant information, at the workplace search engines still do not deliver satisfying results to professionals. Search engines for instance ignore that the relevance of answers (the satisfaction of a searcher’s needs) depends not only on the query (the information request) and the document corpus, but also on the working context (the user’s personal needs, education, etc.). In effect, an answer which might be appropriate to one user might not be appropriate to the other user, even though the query and the document corpus are the same for both. Personalization services addressing the context become therefore more and more popular and are an active field of research. This is only one of several challenges encountered in ‘professional search’: How can the working context of the searcher be incorporated in the ranking process; how can unstructured free-text documents be enriched with semantic information so that the information need can be expressed precisely at query time; how and to which extent can a company’s knowledge be exploited for search purposes; how should data from distributed sources be accessed from into one-single-entry-point. This thesis is devoted to ‘professional search’, i.e. search at the workplace, especially in industrial research and development. We contribute by compiling and developing several approaches for facing the challenges mentioned above. The approaches are implemented into the prototype YASA (Your Adaptive Search Agent) which provides meta-search, adaptive ranking of search results, guided navigation, and which uses domain knowledge to drive the search processes. YASA is deployed in the pharmaceutical research department of Roche in Penzberg – a major pharmaceutical company – in which the applied methods were empirically evaluated. Being confronted with mostly unstructured free-text documents and having barely explicit metadata at hand, we faced a serious challenge. Incorporating semantics (i.e. formal knowledge representation) into the search process can only be as good as the underlying data. Nonetheless, we are able to demonstrate that this issue can be largely compensated by incorporating automatic metadata extraction techniques. The metadata we were able to extract automatically was not perfectly accurate, nor did the ontology we applied contain considerably “rich semantics”. Nonetheless, our results show that already the little semantics incorporated into the search process, suffices to achieve a significant improvement in search and retrieval. We thus contribute to the research field of context-based search by incorporating the working context into the search process – an area which so far has not yet been well studied

SMART CAMP: Environmental Sustainability Through Intelligent Automation Technologies

A "Smart Camp" solution is a new approach to provide a mining community consisting of multiple households in a remote area in Western Australia with a intelligent wireless network and automated information system. This system intends to automate, control and monitor numerous household devices; supplies the tenants with multi-media services and aims to reduce energy consumption as well as improving the workers habitat. This paper theorizes the big picture with considerations on: how to set up, integrate and create a cost-effective "smart" wireless home automation network solution. It attempts to improve employee quality of life while simultaneously reducing energy consumption and the related emissions. Therefore, the latest Wireless Technologies in the field of domotics will be discussed and the importance of environmental sustainability and energy awareness will be outlined

Smart Camp: A Sustainable Digital Ecosystems Environment

Seamlessly integrating energy saving with the habits of daily life is an ambitious goal. It becomes even a bigger challenge in a remote area, like the Western-Australian Outback. Harsh environment, high temperatures and hard working conditions demand great exertion from humans and make one’s well-being an integral part of life. To bring both together – environmental sustainability and life quality – is a new interdisciplinary approach in the field of computer science. A “Smart Camp” is a new low rate wireless personal area network (LR-WPAN)-based solution, which provides accommodations in a remote mining site with a smart automation and information system to contribute toenvironmental sustainability and to provide amenities for its inhabitants. The Smart Camp intends to monitor and control household appliances with the aim to reduce the overall energy consumption. Additionally, multi-media components will be implemented, which aim to make the occupants life more pleasant by adding value to their habitat

Scarcity, alterity and value: decline of the pangolin, the world’s most trafficked mammal

The pangolin, now recognised as the world’s most trafficked mammal, is currently undergoing population collapse across South and Southeast Asia, primarily because of the medicinal value attributed to its meat and scales. This paper explores how scarcity and alterity (otherness) drive the perceived value of these creatures for a range of human and more-than-human stakeholders: wildlife traffickers, Traditional Chinese Medicine (TCM) practitioners, Asian consumers of their meat and scales, hunters and poachers, pangolin-rearing master-spirits, and conservation organisations. Based on archival research and long-term ethnographic study with indigenous hunters in the Eastern Himalayas, the paper analyses the commodity chains linking hunters and consumers of pangolin across South, Southeast and East Asia. It shows that whilst the nonlinear interaction of scarcity, alterity and value is driving the current overexploitation of pangolins, for some indigenous hunters in the Eastern Himalayas, these same dynamics interact to preserve these animals in the forests where they dwell

Spin-polarization-induced structural selectivity in Pd3X_3X and Pt3X_3X (X=3dX=3d) compounds

Spin-polarization is known to lead to important {\it magnetic} and {\it optical} effects in open-shell atoms and elemental solids, but has rarely been implicated in controlling {\it structural} selectivity in compounds and alloys. Here we show that spin-polarized electronic structure calculations are crucial for predicting the correct $T=0$ crystal structures for Pd$_3X$ and Pt$_3X$ compounds. Spin-polarization leads to (i) stabilization of the $L1_2$ structure over the $DO_{22}$ structure in Pt$_3$Cr, Pd$_3$Cr, and Pd$_3$Mn, (ii) to the stabilization of the $DO_{22}$ structure over the $L1_2$ structure in Pd$_3$Co and to (iii) ordering (rather than phase-separation) in Pt$_3$Co and Pd$_3$Cr. The results are analyzed in terms of first-principles local spin density calculations.Comment: 4 pages, REVTEX, 3 eps figures, to appear in PR

Landauer Conductance without Two Chemical Potentials

We present a theory of the four--terminal conductance for the multi-channel tunneling barrier, which is based on the self-consistent solution of Shrodinger, Poisson and continuity equations. We derive new results for the case of a barrier embedded in a long wire with and without disorder. We also recover known expressions for the conductance of the barrier placed into a ballistic constriction. Our approach avoids a problematic use of two chemical potentials in the same system.Comment: 12 page

Solar disinfection (SODIS) of viruses in PET bottles

Solar disinfection of drinking water in PET bottles (SODIS) is a simple point-of-use technique efficient for the inactivation of many bacterial pathogens. In contrast, the efficiency of SODIS toward viruses is not well known. In this work, we studied the inactivation of bacteriophages (MS2 and ɸX174) and human viruses (echovirus 11 and adenovirus type 2) by SODIS. We conducted experiments in PET bottles exposed to (simulated) sunlight at different temperatures (15, 22, 26 and 40°C) and in water sources of diverse composition and origin (India and Switzerland). Good inactivation of MS2 (more than 6-log inactivation after exposure to a total fluence of 1.34 kJ/cm2) was achieved in Swiss tap water at 22°C, while less efficient inactivation was observed in Indian waters and for echovirus (1.5-log at the same fluence). The DNA viruses studied, ɸX174 and adenovirus, were resistant to SODIS and the observed inactivation was equivalent to that occurring in the dark. Temperature enhanced MS2 inactivation substantially; at 40°C, a 3-log inactivation as achieved in Swiss tap water after exposure to a fluence of only 0.18 kJ/cm2. Overall, our findings demonstrate that SODIS may reduce the load of ssRNA viruses such as echoviruses, particularly at high temperatures and in photo-reactive matrices. In contrast, further complementary measures may be needed to ensure an efficient inactivation during SODIS of viruses resistant to oxidation such as ɸX174, or viruses undergoing rapid inactivation in the dark

The impact of a lay counselor led collaborative care intervention for common mental disorders in public and private primary care: a qualitative evaluation nested in the MANAS trial in Goa, India.

The MANAS trial evaluated the effectiveness of a lay counselor led collaborative stepped care intervention for Common Mental Disorders (CMD) in public and private sector primary care settings in Goa, India. This paper describes the qualitative findings of the experience of the intervention and its impact on health and psychosocial outcomes. Twenty four primary care facilities (12 public and private each) were randomized to provide either collaborative stepped care (CSC) or enhanced usual care (EUC) to adults who screen positive for CMDs. Participants were sampled purposively based on two criteria: gender and, in the CSC arm, adherence with the intervention. The qualitative study component involved two semi-structured interviews with participants of both arms (N = 115); the first interview within 2 months of recruitment and the second 6-8 months after recruitment. Data were collected between September 2007 and November 2009. More participants in the CSC than EUC arm reported relief from symptoms and an improvement in social functioning and positive impact on work and activities of daily life. The CSC participants attributed their improvement both to medication received from the doctors and the strategies suggested by the lay Health Counselors (HC). However, two key differences were observed in the results for the two types of facilities. First, the CSC participants in the public sector clinics were more likely to consider the HCs to be an important component of providing care who served as a link between patient and the doctor, provided them skills on stress management and helped in adherence to medication. Second, in the private sector, doctors performed roles similar to those of the HCs and participants in both arms placed much faith in the doctor who acted as a confidante and was perceived to understand the participant's health and context intimately. Lay counselors working in a CSC model have a positive effect on symptomatic relief, social functioning and satisfaction with care in patients with CMD attending primary care clinics although the impact, compared with usual care, is greater in the public sector

Symmetry Energy I: Semi-Infinite Matter

Energy for a nucleus is considered in macroscopic limit, in terms of nucleon numbers. Further considered for a nuclear system is the Hohenberg-Kohn energy functional, in terms of proton and neutron densities. Finally, Skyrme-Hartree-Fock calculations are carried out for a half-infinite particle-stable nuclear-matter. In each case, the attention is focused on the role of neutron-proton asymmetry and on the nuclear symmetry energy. We extend the considerations on the symmetry term from an energy formula to the respective term in the Hohenberg-Kohn functional. We show, in particular, that in the limit of an analytic functional, and subject to possible Coulomb corrections, it is possible to construct isoscalar and isovector densities out of the proton and neutron densities, that retain a universal relation to each other, approximately independent of asymmetry. In the so-called local approximation, the isovector density is inversely proportional to the symmetry energy in uniform matter at the local isoscalar density. Generalized symmetry coefficient of a nuclear system is related, in the analytic limit of a functional, to an integral of the isovector density. We test the relations, inferred from the Hohenberg-Kohn functional, in the Skyrme-Hartree-Fock calculations of half-infinite matter. Within the calculations, we obtain surface symmetry coefficients and parameters characterizing the densities, for the majority of Skyrme parameterizations proposed in the literature. The volume-to-surface symmetry-coefficient ratio and the displacement of nuclear isovector relative to isoscalar surfaces both strongly increase as the slope of symmetry energy in the vicinity of normal density increases.Comment: 87 pages, 18 figures; discussion of Kohn-Sham method added, comparison to results in literature broadene